Establish comprehensive quantitative descriptions and compositions of acto-myosin clusters across systems

Establish comprehensive quantitative descriptions of acto-myosin clusters in cellular systems beyond fission yeast, including determining the molecular composition of clusters in organisms and cell types where the constituent proteins and their abundances have not yet been established.

Background

While fission yeast clusters (nodes) are well characterized, many other systems lack detailed quantitative accounts of cluster composition and dynamics. The review highlights that these gaps hinder cross-system comparisons and mechanistic understanding.

Resolving this will require systematic measurements and analyses of cluster components, assembly sequences, and turnover across diverse biological contexts.