Mitigating retargeting-induced biases for atypical anthropometrics and pathological gait via large-scale physics-based training

Determine whether large-scale training in a physics-based dynamic simulator can mitigate inaccuracies introduced when retargeting SMPL-based motion capture to the MyoFullBody musculoskeletal morphology, particularly for individuals with atypical anthropometrics, asymmetric gait patterns, or musculoskeletal pathologies.

Background

The retargeting pipeline maps SMPL-based motion capture to the musculoskeletal models, but SMPL joints are statistical estimates derived from healthy populations. The authors note that this can misrepresent atypical anthropometrics or pathological conditions, causing discrepancies in joint centers, segment lengths, and moment arms that may smooth out or obscure clinically relevant features after retargeting.

They explicitly identify uncertainty about whether extensive training within a physics-based simulator could compensate for these retargeting shortcomings, posing it as an open question.

References

While our kinematic and kinetic analyses demonstrate accurate predictions during walking and running, this statistical definition may not faithfully represent individuals with atypical anthropometrics, asymmetric gait patterns, or MSK pathologies. When such motions are retargeted, discrepancies in joint centers, segment lengths, and moment arms can propagate through to simulated dynamics, potentially smoothing over or entirely losing the very clinical features of interest. It remains an open question whether large-scale training in a physics-based dynamic simulator could mitigate these shortcomings.

Towards Embodied AI with MuscleMimic: Unlocking full-body musculoskeletal motor learning at scale  (2603.25544 - Li et al., 26 Mar 2026) in Discussion, Retargeted Motions and Dataset (Section 4)