Synchronized Dynamics and Nonequilibrium Steady States in a Stochastic Yeast Cell-Cycle Network

Abstract: Applying the mathematical circulation theory of Markov chains, we investigate the synchronized stochastic dynamics of a discrete network model of yeast cell-cycle regulation where stochasticity has been kept rather than being averaged out. By comparing the network dynamics of the stochastic model with its corresponding deterministic network counterpart, we show that the synchronized dynamics can be soundly characterized by a dominant circulation in the stochastic model, which is the natural generalization of the deterministic limit cycle in the deterministic system. Moreover, the period of the main peak in the power spectrum, which is in common use to characterize the synchronized dynamics, perfectly corresponds to the number of states in the main cycle with dominant circulation. Such a large separation in the magnitude of the circulations, between a dominant, main cycle and the rest, gives rise to the stochastic synchronization phenomenon.