Robust Detection of Periodic Patterns in Gene Expression Microarray Data using Topological Signal Analysis

Abstract: In this paper, we present a new approach for analyzing gene expression data that builds on topological characteristics of time series. Our goal is to identify cell cycle regulated genes in micro array dataset. We construct a point cloud out of time series using delay coordinate embeddings. Persistent homology is utilized to analyse the topology of the point cloud for detection of periodicity. This novel technique is accurate and robust to noise, missing data points and varying sampling intervals. Our experiments using Yeast Saccharomyces cerevisiae dataset substantiate the capabilities of the proposed method.