Optimization of the image contrast in SPECT-CT bremsstrahlung imaging for Selective Internal Radiation Therapy of liver malignancies with Y-90 microspheres

Abstract: The quality of SPECT Bremsstrahlung images of patients treated with Y-90 is poor, mainly because of scattered radiation and collimator septa penetration. To minimize the latter effect, High Energy (HE) or Medium Energy (ME) collimators can be used. Scatter correction is not possible through the methods commonly used for the diagnostic radionuclides (Tc-99m, etc.) because the Bremsstrahlung radiation does not have distinct photopeaks, but a broad spectrum of energies ranging from zero to the maximum one detectable by the gamma-camera crystal is registered. Scatter radiation and collimator septa penetration affect the Contrast and the Contrast Recovery Coefficient (CRC) : our research focused on finding the best energy position for the acquisition window in order to maximize these parameters. To be guided in this finding, we first made a Monte Carlo (MC) simulation of a SPECT acquisition of a Y-90 cylindrical phantom and then we measured at different energies the Line Spread Function (LSF) of a linear Y-90 source inserted in a scatter medium. Finally we acquired the NEMA IEC Body phantom filled with Y-90 chloride at different energies and using different setups in order to measure the Contrast and the CRC in different conditions with the purpose of optimizing the clinical SPECT acquisition procedures. The final results showed that Contrast and CRC are higher for HE collimators compared to ME collimators and they have a maximum for the larger spheres at 110 - 135 keV.