Radiomic Synthesis Using Deep Convolutional Neural Networks

Abstract: Radiomics is a rapidly growing field that deals with modeling the textural information present in the different tissues of interest for clinical decision support. However, the process of generating radiomic images is computationally very expensive and could take substantial time per radiological image for certain higher order features, such as, gray-level co-occurrence matrix(GLCM), even with high-end GPUs. To that end, we developed RadSynth, a deep convolutional neural network(CNN) model, to efficiently generate radiomic images. RadSynth was tested on a breast cancer patient cohort of twenty-four patients(ten benign, ten malignant and four normal) for computation of GLCM entropy images from post-contrast DCE-MRI. RadSynth produced excellent synthetic entropy images compared to traditional GLCM entropy images. The average percentage difference and correlation between the two techniques were 0.07 $\pm$ 0.06 and 0.97, respectively. In conclusion, RadSynth presents a new powerful tool for fast computation and visualization of the textural information present in the radiological images.