Solid-Liquid Transition of Deformable and Overlapping Active Particles

Abstract: Experiments and theory have shown that cell monolayers and epithelial tissues exhibit solid-liquid and glass-liquid transitions. These transitions are biologically relevant to our understanding of embryonic development, wound healing, and cancer. Current models typically consider purely two-dimensional monolayers with no overlaps between neighboring cells. In reality, overlaps are important, and they may be precursors of cell extrusion -- a key biophysical process to maintain homeostasis in epithelial tissues. Here, we use a multi-phase field model to study the solid-liquid transition in a confluent monolayer of deformable cells which can overlap. When cells overlap rather than deform, we find that the melting transition changes from continuous to discontinuous, and that there is an intermittent regime close to the transition, where solid and liquid states alternate over time. By studying the dynamics of $5$- and $7$-fold disclinations in the hexagonal lattice formed by the cell centers, we observe that these correlate with spatial fluctuations in the cellular overlap, and that cell extrusion tends to initiate near $5$-fold disclinations.