Interpreting models of infectious diseases in terms of integral input-to-state stability

Abstract: The notions of integral input-to-state stability (iISS) and input-to-state stability (ISS) have been effective in addressing nonlinearities globally without domain restrictions in analysis and design of control systems. In particular, they provide useful tools of module-based methods integrating characteristics of components. This paper applies the framework of module-based analysis to ordinary differential equations which deterministically describe dynamics of prevalence and the duration of epidemics. The objective is to express fundamental properties of models of infectious diseases and vaccination through the language of iISS and ISS. The systematic treatment is expected to facilitate development of effective schemes of controlling the spread of diseases via non-conventional Lyapunov functions.