SPECT Angle Interpolation Based on Deep Learning Methodologies

Abstract: A novel method for SPECT angle interpolation based on deep learning methodologies is presented. Projection data from software phantoms were used to train the proposed model. For evaluation of the efficacy of the method, phantoms based on Shepp Logan, with various noise levels added were used, and the resulting interpolated sinograms are reconstructed using Ordered Subset Expectation Maximization (OSEM) and compared to the reconstructions of the original sinograms. The proposed method can quadruple the projections, and denoise the original sinogram, in the same process. As the results show, the proposed model significantly improves the reconstruction accuracy. Finally, to demonstrate the efficacy and capability of the proposed method results from real-world DAT-SPECT sinograms are presented.