Proposing a System Level Machine Learning Hybrid Architecture and Approach for a Comprehensive Autism Spectrum Disorder Diagnosis

Abstract: Autism Spectrum Disorder (ASD) is a severe neuropsychiatric disorder that affects intellectual development, social behavior, and facial features, and the number of cases is still significantly increasing. Due to the variety of symptoms ASD displays, the diagnosis process remains challenging, with numerous misdiagnoses as well as lengthy and expensive diagnoses. Fortunately, if ASD is diagnosed and treated early, then the patient will have a much higher chance of developing normally. For an ASD diagnosis, machine learning algorithms can analyze both social behavior and facial features accurately and efficiently, providing an ASD diagnosis in a drastically shorter amount of time than through current clinical diagnosis processes. Therefore, we propose to develop a hybrid architecture fully utilizing both social behavior and facial feature data to improve the accuracy of diagnosing ASD. We first developed a Linear Support Vector Machine for the social behavior based module, which analyzes Autism Diagnostic Observation Schedule (ADOS) social behavior data. For the facial feature based module, a DenseNet model was utilized to analyze facial feature image data. Finally, we implemented our hybrid model by incorporating different features of the Support Vector Machine and the DenseNet into one model. Our results show that the highest accuracy of 87% for ASD diagnosis has been achieved by our proposed hybrid model. The pros and cons of each module will be discussed in this paper.