Data-Consistent Local Superresolution for Medical Imaging

Abstract: In this work we propose a new paradigm of iterative model-based reconstruction algorithms for providing real-time solution for zooming-in and refining a region of interest in medical and clinical tomographic (such as CT/MRI/PET, etc) images. This algorithmic framework is tailor for a clinical need in medical imaging practice, that after a reconstruction of the full tomographic image, the clinician may believe that some critical parts of the image are not clear enough, and may wish to see clearer these regions-of-interest. A naive approach (which is highly not recommended) would be performing the global reconstruction of a higher resolution image, which has two major limitations: firstly, it is computationally inefficient, and secondly, the image regularization is still applied globally which may over-smooth some local regions. Furthermore if one wish to fine-tune the regularization parameter for local parts, it would be computationally infeasible in practice for the case of using global reconstruction. Our new iterative approaches for such tasks are based on jointly utilizing the measurement information, efficient upsampling/downsampling across image spaces, and locally adjusted image prior for efficient and high-quality post-processing. The numerical results in low-dose X-ray CT image local zoom-in demonstrate the effectiveness of our approach.