Abnormal Functional Brain Network Connectivity Associated with Alzheimer's Disease

Abstract: The study's objective is to explore the distinctions in the functional brain network connectivity between Alzheimer's Disease (AD) patients and normal controls using Functional Magnetic Resonance Imaging (fMRI). The study included 590 individuals, with 175 having AD dementia and 415 age-, gender-, and handedness-matched normal controls. The connectivity of functional brain networks was measured using ROI-to-ROI and ROI-to-Voxel connectivity analyses. The findings reveal a general decrease in functional connectivity among the AD group in comparison to the normal control group. These results advance our comprehension of AD pathophysiology and could assist in identifying AD biomarkers.