Missing-modality Enabled Multi-modal Fusion Architecture for Medical Data

Abstract: Fusing multi-modal data can improve the performance of deep learning models. However, missing modalities are common for medical data due to patients' specificity, which is detrimental to the performance of multi-modal models in applications. Therefore, it is critical to adapt the models to missing modalities. This study aimed to develop an efficient multi-modal fusion architecture for medical data that was robust to missing modalities and further improved the performance on disease diagnosis.X-ray chest radiographs for the image modality, radiology reports for the text modality, and structured value data for the tabular data modality were fused in this study. Each modality pair was fused with a Transformer-based bi-modal fusion module, and the three bi-modal fusion modules were then combined into a tri-modal fusion framework. Additionally, multivariate loss functions were introduced into the training process to improve model's robustness to missing modalities in the inference process. Finally, we designed comparison and ablation experiments for validating the effectiveness of the fusion, the robustness to missing modalities and the enhancements from each key component. Experiments were conducted on MIMIC-IV, MIMIC-CXR with the 14-label disease diagnosis task. Areas under the receiver operating characteristic curve (AUROC), the area under the precision-recall curve (AUPRC) were used to evaluate models' performance. The experimental results demonstrated that our proposed multi-modal fusion architecture effectively fused three modalities and showed strong robustness to missing modalities. This method is hopeful to be scaled to more modalities to enhance the clinical practicality of the model.