Optimal Control of Fluid Dosing in Hemorrhage Resuscitation

Abstract: Fluid resuscitation, also called fluid therapy, is commonly used in treatment of critical care patients. Of the variables inherent to fluid therapy treatment, fluid infusion types are well-studied, but volumetric optimization is not. Automated fluid resuscitation systems employ computational control algorithms along with physiological sensors and actuators to automatically adjust the fluid infusion dosage in hemorrhage scenarios. Most automated hemorrhage resuscitation control algorithms implemented to date are of empiric nature and not effective in the presence of clinical disturbances. This work presents preliminary results of a novel controller based on optimal control approach for automated fluid therapy systems. A receding horizon controller is designed to automatically adjust fluid infusion rate in hemorrhagic situations. The proposed control approach aims to address the inefficiency of current resuscitation control algorithms in finding the accurate fluid dosage adjustments. Performance of the proposed approach is compared against a proportional-integral-derivative (PID) controller for a simulated hemorrhage scenario.