Optimizing Temporal Waveform Analysis: A Novel Pipeline for Efficient Characterization of Left Coronary Artery Velocity Profiles

Abstract: Continuously measured arterial blood velocity can provide insight into physiological parameters and potential disease states. The efficient and effective description of the temporal profiles of arterial velocity is crucial for both clinical practice and research. We propose a pipeline to identify the minimum number of points of interest to adequately describe a velocity profile of the left coronary artery. This pipeline employs a novel operation that "stretches" a baseline waveform to quantify the utility of a point in fitting other waveforms. Our study introduces a comprehensive pipeline specifically designed to identify the minimal yet crucial number of points needed to accurately represent the velocity profile of the left coronary artery. Additionally, the only location-dependent portion of this pipeline is the first step, choosing all of the possible points of interest. Hence, this work is broadly applicable to other waveforms. This versatility paves the way for a novel non-frequency domain method that can enhance the analysis of physiological waveforms. Such advancements have potential implications in both research and clinical treatment of various diseases, underscoring the broader applicability and impact.