History-dependence shapes causal inference of brain-behaviour relationships

Abstract: Behavioural and neural time series are often correlated with the past. This history-dependence may represent a fundamental property of the measured variables, or may arise from how confounding variables change over time. Here we argue that undecidability about the ground-truth of history-dependence is a general computational property of systems that exchange information with its environment, and show that the resulting uncertainty has a direct impact on causal inference. We first argue that uncertainty in the ground truth of history-dependence is an inherent property of open systems that cannot be explicitly falsified. Simple model systems are then simulated to show how different assumptions about history-dependence can lead to spurious correlations and statistical properties of data distributions that are typically unaccounted for. We then consider this problem from an interventionist perspective, showing that interventions can only be guaranteed to remedy the spurious correlation problem when the latent dynamics between the intervention and measured processes are known a priori, and the effect of the intervention is invariant at the chosen level of analysis. We conclude that uncertainty about history-dependence is a fundamental property of the study of neural systems, and in light of this discuss how causality should be assessed in neuroscience.