Doppler holography for ophthalmology

Abstract: A comprehensive assessment of retinal health demands reliable and precise methods to measure localized blood perfusion. Despite considerable advancements in imaging techniques, such as indocyanine green and fluorescein angiography, along with optical coherence tomography angiography, their capacity to monitor blood flow dynamics across the cardiac cycle faces significant limitations. For more effective care of those with ocular conditions, innovating new approaches is paramount. Doppler holography, an emerging non-invasive optical imaging technique, meets this challenge by offering high temporal resolution imaging of retinal and choroidal blood flow. Now a burgeoning interdisciplinary research field, Doppler holography intertwines functional optical imaging system design, high-performance computing, and clinical investigation. Through collaborative efforts among universities, industry partners, and ophthalmic clinics, a network for its advancement and application is taking shape. This endeavor promises to propel the discovery of novel functional biomarkers, transforming the diagnosis and treatment of retinal diseases, refining disease severity categorization, and enhancing therapeutic monitoring-ultimately leading to improved healthcare outcomes.