Intra-operative tumour margin evaluation in breast-conserving surgery with deep learning

Abstract: A positive margin may result in an increased risk of local recurrences after breast retention surgery for any malignant tumour. In order to reduce the number of positive margins would offer surgeon real-time intra-operative information on the presence of positive resection margins. This study aims to design an intra-operative tumour margin evaluation scheme by using specimen mammography in breast-conserving surgery. Total of 30 cases were evaluated and compared with the manually determined contours by experienced physicians and pathology report. The proposed method utilizes image thresholding to extract regions of interest and then performs a deep learning model, i.e. SegNet, to segment tumour tissue. The margin width of normal tissues surrounding it is evaluated as the result. The desired size of margin around the tumor was set for 10 mm. The smallest average difference to manual sketched margin (6.53 mm +- 5.84). In the all case, the SegNet architecture was utilized to obtain tissue specimen boundary and tumor contour, respectively. The simulation results indicated that this technology is helpful in discriminating positive from negative margins in the intra-operative setting. The aim of proposed scheme was a potential procedure in the intra-operative measurement system. The experimental results reveal that deep learning techniques can draw results that are consistent with pathology reports.