Multimodal Large Language Models for Bioimage Analysis

Abstract: Rapid advancements in imaging techniques and analytical methods over the past decade have revolutionized our ability to comprehensively probe the biological world at multiple scales, pinpointing the type, quantity, location, and even temporal dynamics of biomolecules. The surge in data complexity and volume presents significant challenges in translating this wealth of information into knowledge. The recently emerged Multimodal LLMs (MLLMs) exhibit strong emergent capacities, such as understanding, analyzing, reasoning, and generalization. With these capabilities, MLLMs hold promise to extract intricate information from biological images and data obtained through various modalities, thereby expediting our biological understanding and aiding in the development of novel computational frameworks. Previously, such capabilities were mostly attributed to humans for interpreting and summarizing meaningful conclusions from comprehensive observations and analysis of biological images. However, the current development of MLLMs shows increasing promise in serving as intelligent assistants or agents for augmenting human researchers in biology research