Mpox Screen Lite: AI-Driven On-Device Offline Mpox Screening for Low-Resource African Mpox Emergency Response

Abstract: Background: The 2024 Mpox outbreak, particularly severe in Africa with clade 1b emergence, has highlighted critical gaps in diagnostic capabilities in resource-limited settings. This study aimed to develop and validate an AI-driven, on-device screening tool for Mpox, designed to function offline in low-resource environments. Methods: We developed a YOLOv8n-based deep learning model trained on 2,700 images (900 each of Mpox, other skin conditions, and normal skin), including synthetic data. The model was validated on 360 images and tested on 540 images. A larger external validation was conducted using 1,500 independent images. Performance metrics included accuracy, precision, recall, F1-score, sensitivity, and specificity. Findings: The model demonstrated high accuracy (96%) in the final test set. For Mpox detection, it achieved 93% precision, 97% recall, and an F1-score of 95%. Sensitivity and specificity for Mpox detection were 97% and 96%, respectively. Performance remained consistent in the larger external validation, confirming the model's robustness and generalizability. Interpretation: This AI-driven screening tool offers a rapid, accurate, and scalable solution for Mpox detection in resource-constrained settings. Its offline functionality and high performance across diverse datasets suggest significant potential for improving Mpox surveillance and management, particularly in areas lacking traditional diagnostic infrastructure.