RNA-Protein Interaction Prediction Based on Deep Learning: A Comprehensive Survey

Abstract: The interaction between Ribonucleic Acids (RNAs) and proteins, also called RNA Protein Interaction (RPI), plays an important role in the life activities of organisms, including in various regulatory processes, such as gene splicing, gene localization, and disease pathogenesis. RPI Prediction (RPIP) predicts the interactions between RNAs and proteins, which includes looking for the existence of interactions and the binding sites of interactions, and adding RNA-protein functional annotations (such as immunity regulation, neuroprotection, etc). Due to the huge amounts of complex biological data, Deep Learning-based RPIP (DL-based RPIP) has been widely investigated, as it can extract high-dimensional features from data and make accurate predictions. Over the last decade, there have been many achievements and contributions in DL-based RPIP. Although some previous studies review DL-based RPIP, to the best of our knowledge, there is still a lack of a comprehensive survey. In this paper, we extensively survey DL-based RPIP in terms of its entire process, including: feature encoding, deep learning modeling, results evaluation, RPIP application domains, and available websites and software. We also identify some open research challenges, and discuss the potential future work for DL-based RPIP.