Diagnosis of Malignant Lymphoma Cancer Using Hybrid Optimized Techniques Based on Dense Neural Networks

Abstract: Lymphoma diagnosis, particularly distinguishing between subtypes, is critical for effective treatment but remains challenging due to the subtle morphological differences in histopathological images. This study presents a novel hybrid deep learning framework that combines DenseNet201 for feature extraction with a Dense Neural Network (DNN) for classification, optimized using the Harris Hawks Optimization (HHO) algorithm. The model was trained on a dataset of 15,000 biopsy images, spanning three lymphoma subtypes: Chronic Lymphocytic Leukemia (CLL), Follicular Lymphoma (FL), and Mantle Cell Lymphoma (MCL). Our approach achieved a testing accuracy of 99.33\%, demonstrating significant improvements in both accuracy and model interpretability. Comprehensive evaluation using precision, recall, F1-score, and ROC-AUC underscores the model's robustness and potential for clinical adoption. This framework offers a scalable solution for improving diagnostic accuracy and efficiency in oncology.