WiseMind: Recontextualizing AI with a Knowledge-Guided, Theory-Informed Multi-Agent Framework for Instrumental and Humanistic Benefits

Abstract: Translating state-of-the-art NLP into practice often stalls at the "last mile" owing to insufficient contextualization of the target domain's knowledge, processes, and evaluation. Psychiatric differential diagnosis exemplifies this challenge: accurate assessments depend on nuanced clinical knowledge, a delicate cognitive-affective interview process, and downstream outcomes that extend far beyond benchmark accuracy. We present WiseMind, a systematic interdisciplinary contextualization framework that delivers both instrumental (diagnostic precision) and humanistic (empathy) gains. WiseMind comprises three components:(i) structured knowledge-guided proactive reasoning, which embeds DSM-5 criteria in a knowledge graph to steer questioning; (ii) a theory-informed dual-agent architecture that coordinates a "reasonable-mind" reasoning agent and an "emotional-mind" empathy agent, inspired by Dialectical Behavior Therapy; and (iii) a multi-faceted evaluation strategy covering simulated patients, user studies, clinician review, and ethical assessment. Tested on depression, anxiety, and bipolar disorder, WiseMind attains up to 84.2% diagnostic accuracy, which is comparable to human experts, while outperforming single-agent baselines in perceived empathy and trustworthiness. These results show that deep contextualization-across knowledge, process, and evaluation layers-can transform benchmark-driven NLP into clinically meaningful impact.