Investigation of pressure balance in proximity of sidewalls in deterministic lateral displacement

Abstract: Deterministic lateral displacement (DLD) is a popular technique for size-based separation of particles. One of the challenges in design of DLD chips is to eliminate the disturbance of fluid flow patterns caused by channel sidewalls intersecting with the pillars matrix. While there are numerous reports in the literature attempting to mitigate this issue by adjusting the gaps between pillars on the sidewalls and the closest ones residing on the bulk grid of DLD array, there are only few works that also configure the axial gap of pillars adjacent to accumulation sidewall to maintain a desired local pressure field. In this work, we study various designs numerically to investigate the effects of geometrical configurations of sidewalls on critical diameter and first stream flux fraction variations across channel. Our results show that regardless of the model used for boundary gap profile, applying a pressure balance scheme can improve the separation performance by reducing the critical diameter variations. In particular, we found that for a given boundary gap distribution, there can be two desired parameter sets with relatively low critical diameter variations. One is related to sufficiently low lateral resistance of interface unit cells next to accumulation sidewall, while the other one emerges by reducing the axial resistance of the interface unit cells to an appropriate extent. We believe that this work can pave the way for designing DLD systems with improved performance, which can be critically important for applications such as separation of rare cells, among others, wherein target species need to be concentrated into as narrow a stream as possible downstream of device to enhance purity and recovery rate simultaneously.