Selective colloid transport across planar polymer brushes

Abstract: Polymer brushes are attractive as surface coatings for a wide range of applications, from fundamental research to everyday life, and also play important roles in biological systems. How colloids (e.g., functional nanoparticles, proteins, viruses) bind and move across polymer brushes is an important yet under-studied problem. We present a mean-field theoretical approach to analyze the binding and transport of colloids in planar polymer brushes. The theory explicitly considers the effect of solvent strength on brush conformation and of colloid-polymer affinity on colloid binding and transport. We derive the position-dependent free energy of the colloid insertion into the polymer brush which controls the rate of colloid transport across the brush. We show how the properties of the brush can be adjusted for brushes to be highly selective, effectively serving as tuneable gates with respect to colloid size and affinity to the brush-forming polymer. The most important parameter regime simultaneously allowing for high brush permeability and selectivity corresponds to a condition when the repulsive and attractive contributions to the colloid insertion free energy nearly cancel. Our theory should be useful to design sensing and purification devices with enhanced selectivity and to better understand mechanisms underpinning the functions of biopolymer brushes.