Pancreatic $β-$Cell Dynamics with Three-Time-Scale Systems

Abstract: Pancreatic $\beta-$cells regulate insulin secretion through complex oscillations, which are vital for glucose control and diabetes research. In this paper, an existing mathematical model of $\beta-$cell dynamics is analyzed using a three-time-scale framework to study interactions among fast, intermediate, and slow variables. Through Geometric Singular Perturbation Theory (GSPT), the influence of ATP on oscillatory dynamics via membrane potential is explored. At the non-hyperbolic point, where standard methods fail, blow-up analysis is applied to investigate canard dynamics shaped by intermediate and slow variables. Numerical simulations with varied parameters reveal the glucose-dependent oscillations linked to slow dynamics near the pseudo-singular points. By leveraging the pseudo-singular point, the linger time is defined, and simulated results for the coupling strength needed for bursting initiation synchronization are presented as a sufficient condition. This study links mathematics and biology, offering insights into diabetic studies.