Variational Learning of Disentangled Representations

Abstract: Disentangled representations enable models to separate factors of variation that are shared across experimental conditions from those that are condition-specific. This separation is essential in domains such as biomedical data analysis, where generalization to new treatments, patients, or species depends on isolating stable biological signals from context-dependent effects. While extensions of the variational autoencoder (VAE) framework have been proposed to address this problem, they frequently suffer from leakage between latent representations, limiting their ability to generalize to unseen conditions. Here, we introduce DISCoVeR, a new variational framework that explicitly separates condition-invariant and condition-specific factors. DISCoVeR integrates three key components: (i) a dual-latent architecture that models shared and specific factors separately; (ii) two parallel reconstructions that ensure both representations remain informative; and (iii) a novel max-min objective that encourages clean separation without relying on handcrafted priors, while making only minimal assumptions. Theoretically, we show that this objective maximizes data likelihood while promoting disentanglement, and that it admits a unique equilibrium. Empirically, we demonstrate that DISCoVeR achieves improved disentanglement on synthetic datasets, natural images, and single-cell RNA-seq data. Together, these results establish DISCoVeR as a principled approach for learning disentangled representations in multi-condition settings.