Generative AI in Science: Applications, Challenges, and Emerging Questions

Abstract: This paper examines the impact of Generative Artificial Intelligence (GenAI) on scientific practices, conducting a qualitative review of selected literature to explore its applications, benefits, and challenges. The review draws on the OpenAlex publication database, using a Boolean search approach to identify scientific literature related to GenAI (including LLMs and ChatGPT). Thirty-nine highly cited papers and commentaries are reviewed and qualitatively coded. Results are categorized by GenAI applications in science, scientific writing, medical practice, and education and training. The analysis finds that while there is a rapid adoption of GenAI in science and science practice, its long-term implications remain unclear, with ongoing uncertainties about its use and governance. The study provides early insights into GenAI's growing role in science and identifies questions for future research in this evolving field.