General mechanism for concentration-based cell size control

Abstract: Cells control their size to cope with noise during growth and division. Eukaryotic cells exhibiting "sizer" control (targeting a specific size before dividing) are thought to rely on molecular concentration thresholds, but simple implementations of this strategy are not stable. We derive a general criterion for concentration-based sizer control and demonstrate it with a mechanistic model that resolves the instability by using multistage progression towards division. We show that if at least one stage has concentration dynamics that are a pure function of size, then sizer control follows for the whole progression. We predict that perturbations to the dynamics shift the size statistics without disrupting sizer control, consistent with recent experiments on fission yeast.