Pan-Cancer mitotic figures detection and domain generalization: MIDOG 2025 Challenge

Abstract: This report details our submission to the Mitotic Domain Generalization (MIDOG) 2025 challenge, which addresses the critical task of mitotic figure detection in histopathology for cancer prognostication. Following the "Bitter Lesson"\cite{sutton2019bitterlesson} principle that emphasizes data scale over algorithmic novelty, we have publicly released two new datasets to bolster training data for both conventional \cite{Shen2024framework} and atypical mitoses \cite{shen_2025_16780587}. Besides, we implement up-to-date training methodologies for both track and reach a Track-1 F1-Score of 0.8407 on our test set, as well as a Track-2 balanced accuracy of 0.9107 for atypical mitotic cell classification.