$\texttt{DiffSyn}$: A Generative Diffusion Approach to Materials Synthesis Planning

Abstract: The synthesis of crystalline materials, such as zeolites, remains a significant challenge due to a high-dimensional synthesis space, intricate structure-synthesis relationships and time-consuming experiments. Considering the one-to-many relationship between structure and synthesis, we propose $\texttt{DiffSyn}$, a generative diffusion model trained on over 23,000 synthesis recipes spanning 50 years of literature. $\texttt{DiffSyn}$ generates probable synthesis routes conditioned on a desired zeolite structure and an organic template. $\texttt{DiffSyn}$ achieves state-of-the-art performance by capturing the multi-modal nature of structure-synthesis relationships. We apply $\texttt{DiffSyn}$ to differentiate among competing phases and generate optimal synthesis routes. As a proof of concept, we synthesize a UFI material using $\texttt{DiffSyn}$-generated synthesis routes. These routes, rationalized by density functional theory binding energies, resulted in the successful synthesis of a UFI material with a high Si/Al$_{\text{ICP}}$ of 19.0, which is expected to improve thermal stability and is higher than that of any previously recorded.