The Multi-View Paradigm Shift in MRI Radiomics: Predicting MGMT Methylation in Glioblastoma

Abstract: Non-invasive inference of molecular tumor characteristics from medical imaging is a central goal of radiogenomics, particularly in glioblastoma (GBM), where O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation carries important prognostic and therapeutic significance. Although radiomics-based machine learning methods have shown promise for this task, conventional unimodal and early-fusion approaches are often limited by high feature redundancy and an incomplete modeling of modality-specific information. In this work, we introduce a multi-view latent representation learning framework based on variational autoencoders (VAE) to integrate complementary radiomic features derived from post-contrast T1-weighted (T1Gd) and Fluid-Attenuated Inversion Recovery (FLAIR) magnetic resonance imaging (MRI). By encoding each modality through an independent probabilistic encoder and performing fusion in a compact latent space, the proposed approach preserves modality-specific structure while enabling effective multimodal integration. The resulting latent embeddings are subsequently used for MGMT promoter methylation classification.