Identify the geographic origin of the East Asian ancestry component in OGVP

Identify the precise geographic source population(s) within East Asia corresponding to the 'East Asian' local ancestry component inferred by RFMix in Oceanian genomes, using expanded reference panels and ancestry-deconvolution methods.

Background

Local ancestry inference in the study relies on four defined ancestry groups: African, European, Papuan, and East Asian. While Papuan ancestry is well characterized using Highland Papua New Guinea references, the East Asian component is broadly defined.

The authors explicitly state that the geographic origin of the East Asian ancestry seen in most Oceanian populations cannot be identified, highlighting a need for refined source-population resolution.

References

The “East Asian” ancestry refer to the ancestry seen in the majority of our Oceanic populations but which geographical origin we cannot identify.

— The Genomic Landscape of Oceania  (2405.09216 - Quinto-Cortés et al., 2024) in Materials and Methods — Ancestry specific analyses