P versus NP
Determine whether the deterministic polynomial-time complexity class P equals the nondeterministic polynomial-time class NP; equivalently, determine whether every decision problem whose solutions can be verified in polynomial time by a deterministic Turing machine can also be solved in polynomial time by a deterministic Turing machine.
References
The Millennium Prize problem P versus NP is one of the current major open questions in computer science.
— Quantum Suicide in Many-Worlds Implies P=NP
(2603.28869 - Baumann et al., 30 Mar 2026) in Section 1 (Introduction), first paragraph; page 1