Representability of wireless and non-synaptic signaling in molecular imaging

Determine which wireless and non-synaptic signaling modalities—including diffusion-based volume transmission, astrocytic coupling, vascular coupling, immune interactions, and extracellular space properties—are reflected in molecular imaging data, and quantify how much of these effects can be utilized to inform parameter inference by an ultrastructure-to-dynamics compiler.

Background

Non-synaptic signaling processes may contribute substantially to neural dynamics but may not be directly visible or quantifiable in standard molecular imaging workflows.

Establishing which components of such signaling are captured by imaging and to what extent they can inform compiled parameters is necessary for assessing the completeness and accuracy of structure-to-function predictions.