Computational models of long term plasticity and memory

Abstract: Memory is often defined as the mental capacity of retaining information about facts, events, procedures and more generally about any type of previous experience. Memories are remembered as long as they influence our thoughts, feelings, and behavior at the present time. Memory is also one of the fundamental components of learning, our ability to acquire any type of knowledge or skills. In the brain it is not easy to identify the physical substrate of memory. Basically, any long-lasting alteration of a biochemical process can be considered a form of memory, although some of these alterations last only a few milliseconds, and most of them, if taken individually, cannot influence our behavior. However, if we want to understand memory, we need to keep in mind that memory is not a unitary phenomenon, and it certainly involves several distinct mechanisms that operate at different spatial and temporal levels. One of the goals of theoretical neuroscience is to try to understand how these processes are orchestrated to store memories rapidly and preserve them over a lifetime. Theorists have mostly focused on synaptic plasticity, as it is one of the most studied memory mechanisms in experimental neuroscience and it is known to be highly effective in training artificial neural networks to perform real world tasks. Some of the synaptic plasticity models are purely phenomenological, some others have been designed to solve computational problems. In this article I will review some of these models and I will try to identify computational principles that underlie memory storage and preservation.